A field experiment was conducted during Rabi season of 2010-11 at College of Agriculture, Pune to study the effect post-emergence herbicides on weeds and productivity of wheat. Among the weed control treatments, application of sulfosulfuron 16.5 g/ha + 2,4-D 563 g/ha registered significantly lower weed population (7.6/m2), dry matter of weeds (3.1 g/m2) and significantly more weed control efficiency of 81.27% than rest of the treatments. The same treatment recorded lowest value of weed index. The values of yield attributes were higher in magnitude in weed free check treatment. Among the herbicide treatments, post-emergence application of sulfosulfuron 16.5 g/ha + 2,4-D 563 g/ha recorded higher values of yield attributes, viz. length of spike, number of spikelets/spike, number of grains/spike, grain weight/plant and thousand seed weight. Amongst the weed control treatments, application of sulfosulfuron 16.5 g/ha + 2,4-D 563 g/ha recorded maximum grain and straw yield of 4.4 and 5.9 t/ha, respectively as compared to other treatments.