The highest weed control efficiency (96.7%). dry root yield (558 kg ha"), seed yield (506 kg ha") and net profit (Rs. 18,450 ha") were recorded with three weedings at 20, 40 and 60 days after sowing (DAS), followed by pre-emergence application of isoproturon at 0.50 kg ha"+weeding at 45 DAS which was followed by glyphosate at 1.0 kg ha"+weeding at 45 DAS. Unchecked weed growth caused 57.2% loss in dry root yield and 53.6% loss in seed yield of asgandh. Higher doses of isoproturon (0.75 kg ha") and glyphosate (1.5 kg ha") gave 8.6 and 13.4% phytotoxicity tel asgandh crop, respectively.