The effect of different herbicides viz. glyphosate (0.5 and 0.75%), metribuzin (0.25 and 0.50%), metsulfuron-methyl (0.005 and 0.01%), 2,4-D EE (0.2 and 0.3%), atrazine (0.2 and 0.3%) was evaluated along with manual weeding (uprooting and cutting), NaCl 20% spray and unsprayed control in waste land at Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahmednagar (M.H.) for two successive years during rabi 2004-05 and 2005-06. Results indicated that application of metribuzin and 2,4-D EE (0.2 and 0.3%) was found more effective for controlling Parthenium at 15 days after spraying. However, spraying of glyphosate (0.50 and 0.75%), atrazine (0.2 and 0.3%), 2,4-D EE and metribuzin recorded significantly lowest weed density and dry matter production and increased weed control efficiency at 30 days after spraying.