An experiment was conducted on Kodo millet during kharif seasons of 2006, 2007 and 2008 at S.G. College of Agriculture and Research Station, Jagdalpur in randomized block design with twelve treatments. Predominant weeds found in weedy check plots were Echinochloa colona, Digitaria sanguinalis Eleusine indica, Celosia argentea, Commelina benghalensis and Euphorbia geniculata. The maximum weed population of broad leaved (224, 420 and 436/m2) and narrow leaved (920, 862 and 963/m2) were found in weedy check in 2006, 2007 and 2008 while dry matter were 278, 267 and 270 and 517, 348 and 325g/m2 for broad and narrow leaved weeds, respectively. Pre-emergence spray of isoproturon 0.5 kg/ha + two inter-cultivations attained significantly higher plant height (60.28, 62.63 and 59.42 cm), number of tillers/plant (4.42, 3.57 and 4.27), number of racemes/plant (6.27, 6.23 and 6.00) and 1000 grain weight (6.30, 6.60 and 6.45g) in Kodo millet over other treatments in consecutive years