A field experiment was conducted during rainy season of 2009 at the Directorate of Sorghum Research, Hyderabad to evaluate the efficacy of new herbicide molecules in grain sorghum. The experimental field was dominated with broad-leaved weeds (66.6%) followed by grasses (27.8%) and sedges (5.6%). Infestation of weeds caused 50% reduction in grain yield of sorghum. Application of oxyfluorefen as pre-emergence, and metsulfuron methyl, carfentrazone, atlantis (mesosulfuron+idosulfuron), almix (chlorimuron+metsulfuron) and total (sulfosulfuron +metsulfuron) as post-emergence caused mild to severe phytotoxicity on grain sorghum resulting in poor yields. This showed that newly developed post-emergence herbicides recommended in other grain crops are not safe for sorghum and therefore, screening of more number of new herbicides is required.