A field study was carried out on sandy loam soils at College Farm, Agricultural College, Mahanandi, Andhra Pradesh during Kharif, 2024 to assess the efficacy of herbicide mixtures on weeds, growth and yield of groundnut (Arachis hypogaea L.). The experiment comprised of ten weed management treatments and was laid out in randomized block design with three replications. The weed density and biomass were significantly lower with hand weeding twice at 20 and 40 days after sowing (DAS) and it was closely followed by pre-emergence application (PE) of diclosulam + pendimethalin 20 + 680 g/ha followed by (fb) hand weeding at 40 DAS. Higher groundnut plant height, dry matter accumulation, pod yield, haulm yield and benefit-cost ratio were recorded with hand weeding twice at 20 and 40 DAS which was at par with diclosulam + pendimethalin 20 + 680 g/ha PE fb hand weeding at 40 DAS.