The experiment was conducted at the Agricultural Research Station, Adilabad, Professor Jayashankar Telangana State Agricultural University (PJTSAU), Telangana during Kharif, 2022 to assess the efficacy of weed management treatments on weed control, soybean productivity and profitability and identify effective and economical option. A randomized block design with 11 treatments replicated thrice was used. Among herbicidal treatments, pre-emergence application (PE) diclosulam 26 g/ha followed by (fb) post-emergence application (PoE) of fluazifop-p-butyl + fomesafen 250 g/ha recorded highest soybean seed yield, gross returns and net returns which was comparable with imazethapyr +pendimethalin 960 g/ha PE fb fluazifop-p-butyl + fomesafen 250 g/ha PoE.