Indiscriminate use of herbicides may raise human and animal health and environmental concerns due to residues on consumables and soil.  Hence, field experiments were conducted during rabi season of 2021-22 and 2022-23 at PAU Ludhiana and KVK Sri Muktsar Sahib, Punjab, India. The objectives were to assess efficacy of metribuzin + clodinafop-propargyl (ready-mix) in managing weeds in wheat and quantify its residues retained in soil and in wheat produce. It involved spray of metribuzin and clodinafop-propargyl (ready-mix) at rates of 275, 220 and 165 g/ha along with unsprayed for weed management in surface seeded wheat. Metribuzin and clodinafop-propargyl at 275 and 220 g/ha significantly lowered weed density and biomass and improved wheat grain yield compared to its lowest dose of 165 g/ha and unsprayed control. Metribuzin and clodinafop-propargyl residues in soil and crop produce were assessed at harvest time and it was observed that their residue levels were below detectable limits (<0.01 µg/g) and below the maximum residue limit fixed by Food Safety and Standards Authority of India (FSSAI), indicating metribuzin + clodinafop-propargyl safety to use as an herbicide in wheat production and consumption of wheat produced after its usage.