Johnsongrass [Sorghum halepense (L.) Pers.] is a menace in several crops including grain sorghum, maize, cotton, soybean, etc. due to its ability to compete for space, nutrients, and light. It is classified as one of the world’s worst weeds and is a target for eradication efforts worldwide. While prevention remains the most effective strategy for managing its spread to new areas, an alternative approach involves leveraging its economic potential through applications such as animal feed, manure, bioremediation, soil binder, etc. For example, johnsongrass serves as fodder grass in many regions, boasting high protein content (10-12% dry matter) and total digestible nutrients (50-60%). Similarly, it exhibits phytoremediation properties, extracting pollutants from soil and water. Despite its potential, research into the utilization of johnsongrass remains limited. Therefore, this article seeks to consolidate the available knowledge on its economic applications, including its genetic potential in sorghum breeding, role as livestock feed, human health benefits, soil conservation properties, industrial uses, etc. By shedding light on the diverse uses of johnsongrass, this article aims to promote awareness and encourage the transformation of noxious weeds into sources of wealth.