A field experiment was carried out at Research Farm of Dr. Rajendra Prasad Central Agricultural University, Pusa, Bihar during 2014-15 and 2015-16 to evaluate the effect of different weed management practices on yield and economics of tobacco. Five weed management treatments were tried out in a randomized block design with four replications. The results revealed that application of neem cake 200 kg/ha at sowing fb soil drenching of metalaxyl MZ 0.2% at 20 DAP recorded the lowest broomrape population of 11.71 and 12.05/plant and maximum tobacco yield of 2.45 and 2.39 t/ha in both the years, respectively. Highest B : C (2.20) was obtained with neem cake 200 kg/ha at sowing followed by (fb) soil drenching of metalaxyl MZ 0.2% at 20 DAP followed by soil drenching of metalaxyl MZ 0.2% at 20 DAP. Hence, it was concluded that for better tobacco yield and broomrape (Orobanche spp.) control, neem cake 200 kg/ha at sowing fb soil drenching of metalaxyl MZ 0.2% at 20 DAP was found to be the best practice.