A field experiment was conducted during rainy season of 2018 in Norman. E. Borlaug. Crop Research Centre of GBPUA&T, Pantnagar with the objective to find the best weed control method among the application of herbicides alone, their tank mix application, sequential application and integration with cultural methods to control the complex weed flora of Kharif  (rainy) maize and to study its effect on the growth and yield. The experiment was laid out in a randomized block design with three replications and ten treatments, viz. atrazine 1.0 kg/ha, tembotrione 120 g/ha, halosulfuron-methyl 67.5 g/ha, atrazine 1.0 kg/ha fb halosulfuron-methyl 54 g/ha, atrazine 800 g/ha fb halosulfuron-methyl 67.5 g/ha, tembotrione 120 g/ha + halosulfuron-methyl 54 g/ha, tembotrione 96 g/ha + halosulfuron-methyl 67.5 g/ha, atrazine 1.0 kg/ha fb one hand weeding at 25 DAS, weed free and weedy check. Among the weed control treatments, pre-emergence application of atrazine 1.0 kg/ha followed by one hand weeding at 25 DAS was the best weed control method which significantly reduced total weed density as well as total dry matter and significantly increased grain and straw yield, weed control efficiency and B:C ratio. This treatment bargained the yield reduction at 3.1% as compared to weedy check (53.1%) reducing the crop-weed competition. Tank mix application of tembotrione 120 g and halosulfuron-methyl 54 g/ha at 3-4 leaf stage of weeds was found to be at par to this treatment.