Lab and field experiments were conducted to investigate the synergistic effects of safener isoxadifen-ethyl on tembotrione (TBT) persistence, sorption and leaching behavior in maize cultivated Inceptisol. Batch sorption indicated that the most stable time of its sorption in Inceptisol is 12 h irrespective of safener addition. Tembotrione showed moderate affinity to soil solids with Kfoc values of 17.08 - 26.29. Tembotrione dissipation followed first-order kinetics with a mean half-life of 15 days and was influenced by application rate, safener, soil pH and organic carbon content. Terminal residue in maize grain was below minimum residue limit set by European Food Safety Standard (0.02 mg/kg), though detected (0.012 mg/kg) above detection limit in soil applied with double recommended rate of TBT. The weed control efficiency was 62.37 and 61.35 percent respectively in recommended and double recommended rate and produced higher grain yield too. Study authenticated that the TBT 120 g/ha with safener, isoxadifen-ethyl 1000 mL/ha is safe to soil environment and provide effective weed control in maize under tropical Inceptisols.