A field experiment was conducted to study the effect of tillage and herbicidal weed management on soybean-wheat sequence during 2021-22. Four tillage treatments were given in main plot for soybean during Kharif; conventional tillage (CT: ploughing 2 harrowing tyne cultivator + harrowing with blade harrow), reduced tillage (RT: harrowing with tyne cultivator + rototill), minimum tillage (MT: rototill), zero tillage and in wheat uniform rototill was given to conventional tillage to minimum tillage (MT: rototill) treatments excluding zero tillage treatment where soybean crop residue was used for soil cover while the sub-plot treatments with five weed management treatments namely; sulfosulfuron + metsulfuron 0.030 kg/ha at 30 DAS, mesosulfuron + iodosulfuron 0.0144 kg/ha at 30 DAS, clodinafop + metsulfuron 0.064 kg/ha at 30 DAS, weed-free (3 HW at 20, 40 and 60 DAS), weedy check. The results indicated that the total weed density, weed dry matter and wheat grain yield were significantly influenced by various tillage practices at all stages of crop growth. Conventional tillage in the kharif and rototill in rabi season was found statistically most superior in respect to lowest weed density, weed dry matter, higher yield and economic returns over rest of the tillage treatments. However, the significantly highest value of total weed density and weed dry matter was recorded with zero tillage. Among the different herbicidal treatments, minimum weed density, weed dry weight, maximum yield and economic benefit was achieved with ready mix application of clodinafop + metsulfuron 0.064 kg/ha applied at 30 DAS.