Due to the water issue and labour shortage during cultivation of rice in India, there is an urgent need to shift towards the alternatives of puddled transplanted rice. Therefore, direct-seeded rice (DSR) is emerging as a productive technique in place of puddle transplanted rice to tackle this situation. The primary biological obstacles to its success, however, are weeds. Therefore, a study has been conducted comprising of 10 treatments with three replications in direct-seeded rice cv. ‘Basmati 370’ during the Kharif (rainy) seasons of 2018 and 2019 at Research Farm of AICRP-Weed Management, Chatha, SKUAST-Jammu in a randomized block design. At 60 DAS, significantly lowest density as well as biomass of grassy weeds were recorded in oxyfluorfen 175 g/ha as pre-emergence (PE) fb fenoxaprop-p-ethyl + 2,4-D-EE (60+500 g/ha) at 25 days after sowing (DAS). However, significantly lowest Cyperus species density and biomass was noticed in pendimethalin 1000 g/ha as PE fb bispyribac-sodium 25 g/ha at 25 days after sowing. More than 80% weed control efficiency was observed in oxyfluorfen 175 g/ha as pre-emergence (PE) fb fenoxaprop-p-ethyl + 2,4-D-EE (60+500 g/ha), pendimethalin 1000 g/ha as PE fb bispyribac-sodium 25 g/ha and pretilachlor 600 g/ha fb penoxsulam + cyhalofop-butyl 150 g/ha. In addition to this, the results revealed that significantly higher grain and straw yield of rice with highest net returns and benefit cost ratio were observed in pendimethalin 1000 g/ha as PE fb bispyribac-sodium 25 g/ha at 25 DAS. The findings of this study will help farmers who are cultivating direct-seeded rice to make decisions on the application of herbicides based on the weed flora existing in the field.