A field experiment was carried out during Kharif season of 2016 at Agricultural Research Farm of Tirhut College of Agriculture, Dholi, Dr. RPCAU, Pusa to evaluate the efficacy of weed management treatments in soybean and identify most effective and economic weed management method. The experiment consisted of nine weed management treatments which were replicated thrice in randomized block design. Weed free [hand weeding twice 20 and 40 days after sowing (DAS)] followed by pre-emergence application (PE) of pendimethalin 1.0 kg/ha along with post-emergence application (PoE) of quizalofop-ethyl 50 g/ha at 25 DAS have significantly reduced total weed density and biomass and attained the highest weed control efficiency and soybean yield. The net returns and B:C were significantly higher with pendimethalin 1.0 kg/ha PE along with quizalofop-ethyl 50 g/ha PoE at 25 DAS due to lesser cost of herbicides usage compared to hand weeding.