Manipulation of crop fertilization with weed management is a promising agronomic practice in reducing weed interference in crops. With this hypothesis, an experiment was conducted at the Birsa Agricultural University, Ranchi, Jharkhand, India during rainy seasons (Kharif) of 2018 and 2019 to study the effect of nutrient and weed management practices on dry direct-seeded rice under split plot design. 100:50:40 kg/ha of N:P:K along with pretilachlor 750 g/ha (pre-emergence) fb bispyribac-Na 25 g/ha (post-emergence) recorded highest grain yield (5.54 t/ha)owing to higher effective tillers and grains/panicle to the extent of 73.5 and 82.8 percent, respectively compared to the minimum attained under lowest nutrient level 60:30:20 kg/ha of N:P:K under weedy check. The combination of 100:50:40 kg/ha of N:P:K along with pretilachlor750 g/ha fb bispyribac-Na 25 g/ha recorded maximum weed management index (5.11) and agronomic management index (4.11) at 60 DAS and higher gross returns ( 1,16928/ha), net returns ( 93376/ha) and B:C (3.13) as compared to rest of the treatment combinations.