Field experiment was conducted at Agronomy Farm, College of Horticulture, Vellanikkara during Kharif (rainy season) 2019 to develop cost-effective weed management strategy for upland rice in Kerala. Treatments consisted of brown manuring (cowpea) by application of 2,4-D 1.0 kg/ha at 25 days after sowing (DAS); in situ green manuring (cowpea) at 25 DAS; oxyfluorfen 0.15 kg/ha on the day of sowing fb hand weeding (HW) at 30 DAS; oxyfluorfen 0.15 kg/ha on the day of sowing fb bispyribac-sodium 0.025 kg/ha at 20 DAS; pyrazosulfuron-ethyl 0.03 kg/ha at 6 DAS fb HW at 30 DAS; pyrazosulfuron-ethyl 0.03 kg/ha at 6 DAS fb bispyribac-sodium 0.025 kg/ha at 20 DAS. Hand weeded control and unweeded control were also maintained. Results revealed that application of oxyfluorfen at 0.15 kg/ha on the day of sowing fb hand weeding at 30 DAS recorded lesser weed density and dry matter production, higher grain (2.74 t/ha) and straw (5.89 t/ha) yields and net monetary returns. It was at par with pyrazosulfuron-ethyl 0.03 kg/ha at 6 DAS fb hand weeding at 30 DAS.