A field investigation was carried out at Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola during three consecutive Kharif seasons (2016-2018) to study the relative efficacy of herbicides on weed control in maize. Results revealed that, among the herbicidal treatments, atrazine 0.5 kg/ha fb tembotrione 0.120 kg/ha PoE at 20 DAS produced less weed count and weed dry matter than rest of the herbicides. Among the herbicidal treatments, maximum growth and yield attributes were recorded with treatment of atrazine 0.5 kg/ha fb tembotrione 0.120 kg/ha which was at par with atrazine 0.5 kg/ha fb 2,4-D sodium salt 0.5 kg/ha. Yield reduction varied from 12.49% to 54.17% in the herbicide applied plots as compared to weed free treatment. Atrazine 0.5 kg/ha fb tembotrione 0.120 kg/ha PoE 20 DAS (4.33 t/ha) and atrazine 1.0 kg/ha PE (3.89 t/ha) proved as effective as weed free treatment (4.91 t/ha) and recorded significantly higher grain yield with net monitory returns of  47832/ha and B:C ratio of 3.22.