A field experiment was conducted during 2014-15 and 2015-16 to study the efficacy of herbicides for control of diverse weeds in barley. Herbicides were sprayed alone or in combinations. The highest grain yield (5.54-6.07 t/ha) was recorded in weed-free treatment which was at par with isoproturon 750 g/ha + 2,4-D 500 g/ha and pinoxaden 40 g/ha + carfentrazone 20 g/ha. Uncontrolled weed competition caused an average 8-54% yield reductions compared to weed-free treatment. The magnitude of net returns and the benefit-cost ratio was higher with the applications of isoproturon 750 g/ha + 2,4-D (Na salt) 500 g/ha, pinoxaden 40 g/ha + carfentrazone 20 g/ha, isoproturon 750 g/ha + metsulfuron 4 g/ha and pinoxaden 40 g/ha followed by metsulfuron 4 g/ha and in weed-free.