The performance of different herbicides for the weed control of dry direct-seeded rice (DDSR) under zero tillage was evaluated by field experiment during rainy season of 2017 at NARC, Lalitpur, Nepal. The treatments consisted of 8 different herbicidal treatments (pendimethalin 1.0 kg/ha, pendimethalin 1 kg/ha followed by bispyribac-Na 35 g/ha, pendimethalin 1.0 kg/ha followed by (fb) tank mix of pyrazosulfuron 20 g/ha + bispyribac-Na 25 g/ha, pendimethalin 1.0 kg/ha fb 2,4-D 1.0 kg/ha, pendimethalin 1.0 kg/ha fb pyrazosulfuron 20 g/ha, pendimethalin 1.0 kg/ha fb penoxsulam 14 g/ha, pendimethalin 1.0 kg/ha fb sulfosulfuron 30 g/ha, pendimethalin 1.0 kg/ha fb 2,4-D 1.0 kg/ha under co-culture with Sesbania) and a weedy check treatment with 3 replications under randomized complete block design. Result of the experiment revealed significant reduction in the weed density and increase in rice yield due to application of herbicides. Sequential application of pendimethalin (pre) fb tank mixture of pyrazosulfuron + bispyribac-Na (post) possess higher weed control efficiency and yielded the highest rice grain yield (3.78 t/ha), which was statistically at par with pendimethalin fb 2,4-D under Sesbania co-culture (3.44 t/ha) and pendimethalin 1.0 kg/ha fb penoxsulam 14 g/ha (3.09 t/ha). Similarly, application of pendimethalin 1.0 kg/ha (pre) fb tank mixture of pyrazosulfuron 20 g/ha + bispyribac-Na 25 g/ha recorded the highest net returns of NRs. 31,760/ha and B: C ratio of 1.42 resulting to be the most economical and efficient herbicidal treatment option in DDSR under zero tillage.