Application of ready-mix herbicides containing two active ingredients in rice to manage broad group of weeds is in practice currently. Among different ready mix formulations, one comprising pyrazosulfuron-ethyl and pretilachlor have been recently registered in India. Though, the persistence of each herbicide in soil under rice as single formulation was reported, the information on persistence of herbicides from ready-mix formulations is not reported under semi-arid tropical conditions of India. Hence, an experiment was conducted to study the dissipation and fate of these ready-mix formulation herbicides in rice soil, water and in rice grain. Pyrazosulfuron-ethyl and pretilachlor residues were determined using high performance liquid chromatograph (HPLC) and gas chromatograph (GC), respectively. The average recoveries of pyrazosulfuron-ethyl and pretilachlor from matrix ranged from 80.3-103.3% with less than 10% standard deviation and sensitivity up to 0.001 µg/g. Both herbicides showed rapid dissipation in rice field water than soil and the degradation followed first order reaction kinetics. While pyrazosulfuron-ethyl dissipated with a half-life of 2.17-5.45 and 0.77-0.79 days respectively in rice field soil and water, pretilachlor dissipated with a half-life of 5.18–6.68 days in soil and 2.59–3.00 days in field water. Pyrazosulfuron-ethyl has shorter half-life than pretilachlor and both the active ingredients dissipated rapidly in rice field soil than water. At harvest, the residues of both the herbicides in rice grain and straw were below the MRLs set by FSSAI