A systemic field study on bioefficacy of different herbicides in greengram (Vigna radiata L.) under irrigated condition of Gujarat and its residual effect on succeeding mustard crop was conducted during Kharif 2014 and 2015 at AAU, Anand. Among the tested options, hand hoeing at 20 and 40 days after sowing (DAS) and pre-emergence (PE) application of imazethapyr + pendimethalin ready mix (RM) at 1000 g/ha proved their supremacy in achieving highest seed yield (1.45 and 1.43 t/ha) with highest B:C of 2.91 & 2.88, respectively. These treatments provided season long control of weeds with the weed control efficiency (WCE) of 93% and 89%, respectively. Moreover, post-emergence (PoE) application of imazethapyr 70 and 80 g/ha or imazethapyr + imazamox ready mix (RM) 80 g/ha provided excellent WCE of more than 85%, but posed their negative impact on symbiotic parameters such as nodule number, plant dry weight and secured lower net return. Treatment receiving pre-emergence application of imazethapyr 80 g/ha was only found superior to achieve all profits with low input cost but did not control weeds effectively. Additionally, imazethapyr and its ready mix combination irrespective of dose did not show any residual effect to succeeding mustard crop.