Based on two years’ field investigation, it was found that sulfosulfuron at 25 g/ha reduced density and dry weight of total weeds to the extent of more than 70% at different growth stages of wheat. This led to a significant increase in the number of effective tillers, 1000-grain weight and ultimately grain of wheat. However, grain yields of wheat were significantly more in the plots kept weed free throughout the crop season. Among 10 wheat cultivars, PBW 343, WH 542 and HD 2687 being at par with each other proved more competitive against weeds and consequently produced more grain yield. Whereas WH 711, WH 533 and Raj 3765 turned out to be poor competitors and lower yielders. On an average, weeds reduced the grain yield of wheat to the tune of 22% over the years.