Field studies conducted during kharif season 2003 at UAS, Dharwad revealed that post emergence application of imazethapyr 75 g/ha alone and with hand weeding was most effective in minimizing weed growth and enhancing the grain yield of soybean (Glycine max (L)). Although recommended soybean herbicides, viz., chlorimuron ethyl and pendimethalin reduced the dry weed bio-mass markedly compared with weedy plot both were found inferior to weed free check. Soybean grain yield due to weed free check was similar to that of imazethapyr 75 g/ha alone and with hand weeding and imazethapyr 100 g/ha fb HW. Crop phytotoxicity symptoms were not observed in soybean due to application of imazethapyr. Imazethapyr 75 g/ha was found also effective provided profitable and comparable with other treatments