25 field demonstrations were laid out during the rabi seasons of 2002-03 to 2004-05 in randomly selected two villages (Kushner and Chheri Boroda) adjoining to the National Reserach Centre for Weed Scienc, Jabalpur (Madhya Pradesh) with an objective to demonstrate the performance and profitability of zero tillage and herbicides on weed and productivity of wheat crop under rice-wheat system at farmers’ fields. Higher weed density and population of Phalaris minor were recorded in conventional tillage than zero tillage. Maximum reduction in weed density was obtained with the application of 2,4-D and isoproturon (500g + 750 g/ha) as tank mix under ZT and CT system. Higher average grain yield and monetary returns due to treatment were also achieved under zero tillage wheat with tank mixed application of 2,4-D and isoproturon as post emergence. Yield achieved in zero tillage was comparable to conventional tillage with clodinafop application.