An experiment was conducted during rabi season of 2006-07 and 2007-08 to evaluate the effect of time of application on the efficacy of Combi (mixture of glyphosate 35% + 2,4-D 35%) and glyphosate alone against weeds particularly Paragrass (Brachiaria mutica) in noncropped area. All the herbicidal treatments had marked influence on the density, dry weight, shoot length and root length of Brachiaria mutica. Application of combinations 2.5 kg/ha during noon hours (12.00-14.00) totally killed Brachiaria mutica within 60 days in comparison of its evening and morning application as well as aplication of glyphosate alone at 2.0 and 2.5 kg/ha at the same time (noon), which took longer time ( 90 days) for total weed kill