A field experiment was conducted during the Rabi (winter) season of 2016-17 at Agricultural Farm, Institute of Agriculture, Visva-Bharati, Sriniketan, West Bengal to study the effect of tillage and weed management on weed growth, productivity and profitability of wheat. The experiment was laid out in a split-plot design with three replications comprising of two tillage and six weed management practices in main and sub plots, respectively. Results showed that zero tillage registered significantly lower density of grasses and total weeds as compared to conventional tillage. Among the weed management practices, weed free plot registered significantly higher grain yield (3.6 t/ha), which was statistically at par with the application of both the doses (25 and 35 g/ha) of sulfosulfuron ethyl + metsulfuron-methyl and clodinafop-propargyl + metsulfuron-methyl 96 g/ha. Zero tillage with the application of sulfosulfuron-ethyl 75% + metsulfuron-methyl 5% WG 35 g/ha fetched the highest net return ( 40,119/ha) and return per rupee invested (2.3), which was comparable with sulfosulfuron-ethyl 75% + metsulfuron-methyl 5% WG 25 g/ha. Thus, in late sown wheat, zero tillage along with pre-mix application of sulfosulfuron-ethyl 75% + metsulfuron-methyl 5% WG 25-35 g/ha and clodinafop-propargyl + metsulfuron-methyl 96 g/ha at 30 DAS appeared to be promising for effective weed control and higher productivity as well as profitability.