Weed management and planting methods in potato cultivation affect the tuber yield and quality significantly, and hence, requires proper management. Therefore, to explore the possibilities of developing a pre-emergence (PE) herbicide application system for potato planter specially for cut seed pieces (tubers) a study was conducted at ICAR-Directorate of Weed Research (DWR) during Rabi season of 2017-18 and 2018-19. The study includes different sprout-eye orientation of the potato tubers along with different weed management practices. The application of metribuzin at 0.75 kg/ha as PE effectively controlled the weeds and obtained a weed density of 2.43 and 2.04 weeds/m2 and weed dry biomass of 1.35 and 1.64 g/m2 respectively at 25 and 55 DAP. By application of the metribuzin as PE and paraquat as early-post emergence (PoE), the tuber yield was increased from 9-16.5%. The sprout-eye orientation has significant effect on tuber yield. The tuber yield was reduced by 28.3% and 16.7% respectively, in 2700 sprout-eye orientation and random dropping over sprout-eye orientation of 90±300. The highest tuber yield of 28.4 t/ha was obtained in planting of whole tuber having the size of 40 to 50 g per tuber. The application of metribuzin as PE effectively controlled the weeds, thus a PE applicator system can be developed along with the potato planter.