A field experiment was conducted at College of Agriculture, S K Rajasthan Agricultural University, Bikaner during rainy season 2015 to find out the efficacy of herbicides for control of weeds in mothbean (Vigna aconitifolia). The experiment comprised of 16 treatment combinations. Application of imazethapyr + imazamox 50 g/ha  (20 DAS) + hand weeding at 35 DAS were significantly superior in reducing weed density and dry weight of both broad-leaved and grassy weeds. Weed free, pendimethalin 0.75 kg/ha + hand weeding at 25 DAS and pendimethalin 0.75 kg/ha PE alone, imazethapyr + imazamox 50 g/ha + hand weeding at 35 DAS and imazethapyr + imazamox 30 g/ha + hand weeding at 35 DAS registered 844, 827, 805, 801 and 781 kg/ha seed yield, respectively as against the seed yield of 427 kg/ha in weedy check. Among the weed control treatments, maximum net returns of ` 50529/ha was recorded under weed free treatment while highest B:C ratio was recorded with pendimethalin 0.75 kg/ha (2.48) closely followed by imazethapyr + imazamox 50 g/ha  + hand weeding at 35 DAS (2.47)