A field experiment was conducted to evaluate the efficacy of halosulfuron-methyl for the control of Cyperus spp. in bottle gourd. The treatments constituted of halosulfuron-methyl at two doses (52.5 and 67.5 g/ha) applied at 3-4 leaf stages of sedges, which was compared with recommended dose of metribuzin (490 g/ha) as pre-emergence, two hand weeding (20 and 35 DAS) and unweeded check. The results revealed that all the weed control treatments significantly reduced Cyperus spp. density as compared to unweeded check except metribuzin 490 g/ha. The lowest weed biomass of Cyperus spp. was recorded with application of halosulfuron-methyl at higher dose (67.5 g/ha) which was significantly lower than halosulfuron-methyl 52.5 g/ha and metribuzin 490 g/ha. Significantly highest fruit yield of bottle gourd was recorded with application of halosulfuron-methyl 67.5 g/ha than other treatments. The herbicide tested in this study did not show any adverse effect on germination and grain yield of succeeding wheat crop.